The effect of intraperitonelly administered higenamine on the cytochrome P -450, b5, P - nitroanisole O - demethyiase and lipid peroxidation in the rat hepatic microsomes were determined.
The following results were obtained
1) The intraperitonelly administered higenamine increased contents of rat hepatic microsomal cytochrome P - 450 and b,,.
2) The principal role of cytochrome P450 in mixed function oxidase reactions includes hydroxylationof various drugs, fatty acids, steroids, pesticides and carcinogens. The increased cytochrome P- 450 induced by higenamine decreased on the both AAF of N - hydroxylation and Ring - hydroxylation.
3) Activity of P - nitroanisole - O - demethylase in hepatic microsomes with higenamine was decreased `accorting to incresed dosage of higenamine.
rj 4) The formation of lipid peroxides was increased according to increased dosage of higenamine.
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